Dr. Martin Greenall
Lecturer, Aberystwyth University
Telephone +44 (0)1970 628624
My research centres on the modelling of the self-assembly of amphiphilic molecules in solution. I have also worked on other topics, including glass formation and fluids at interfaces.
J. Greenall and C. M. Marques. Can adding oil control domain formation in binary amphiphile bilayers? Soft Matter 10 7925 (2014).
J. Greenall and C. M. Marques. Can Amphiphile Architecture Directly Control Vesicle Size? Phys. Rev. Lett. 110 088301 (2013).
J. Greenall and G. Gompper. Simple and complex micelles in amphiphilic mixtures: a coarse-grained mean-field theory study. Macromolecules 45 525 (2012).
J. Greenall, P. Schuetz, S. Furzeland, D. Atkins, D. M. A. Buzza, M. F. Butler and T. C. B. McLeish. Controlling the self-assembly of binary copolymer mixtures in solution through molecular architecture. Macromolecules 44 5510 (2011).
Modelling of micelles and vesicles for drug delivery
Micelles and vesicles formed of amphiphilic molecules can be used to encapsulate drugs for targeted delivery. A challenge in this field is to understand how the properties of micelles and vesicles, such as their size and internal structure, depend on the architecture of the molecules from which they are formed. Since the synthesis of new molecules can be costly and time-consuming, there is a clear need for mathematical and computational modelling to guide experimental work. In this talk, I will introduce the powerful technique of self-consistent field theory (SCFT), and present results on its applications to three problems, all of relevance to drug delivery: fixing the size of vesicles, producing micelles with a high content of hydrophobic material and controlling domain formation in amphiphilic bilayers.
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School of Chemistry, Bangor University, Bangor, Gwynedd, LL57 2UW, UK
Direct Line: 0044 1248 383741 email: firstname.lastname@example.org