The development of a sepsis sensor

Project Overview:

Previous work at Bangor has shown that a dye can be manipulated within a solid matrix material. As part of the CALIN program, continued work will allow the rigorous evaluation to be conducted in order to show that a fully integrated diagnostic device can be developed. Partners: Bangor University & University College Cork

The project originated from initial work conducted in 2012 at Bangor on the manipulation of molecules within a solid matrix material. The first data sets conducted at Bangor showed that a dye placed within a solid matrix could be controlled accurately within a specific area of the matrix. Follow-on experiments with nucleic acid-based bioassays showed that molecular-based reactions could be conducted within a solid matrix. These initial experiments illustrated the basic proof of principle. However, a rigorous evaluation needs to be conducted in order to show that a fully integrated device can be developed, where sample preparation, nucleic acid amplification, and detection, can all be performed within a single solid matrix-based device.

This project will be carried out in collaboration with University College Cork ireland-walesThe project has been part-funded by the European Regional Development Fund through the Ireland Wales Cooperation programme

Publications:

A. J. Heeroma and C. D. Gwenin, Development of solid-phase RPA on a lateral flow device for the detection of pathogens related to Sepsis, Sensors, 20(15), 4182, (2020) DOI.org/10.3390/s20154182